| Kick-off | |||
| Zaterdag 18-9-2021 Colts | Oemoemenoe/etc/Eilanders CO 1 | Aachen/Maastricht CO 1 | 13.00h |
| Zondag 19-9-2021 | TRSC Tarantula | MRC 2 | 15.00h |
| Zaterdag 25-9-2021 Colts | Aachen/Maastricht CO 1 | ZeBra Tovaal/RCC CO 1 | 13.00h |
| Zondag 26-9-2021 |
MRC2 |
The Elephants 1 |
15.00h |
| Zaterdag 02-10-2021 Colts | RC Hilversum CO 1 | Aachen/Maastricht CO 1 | 13.00h |
| Zondag 03-102021 |
NRC The Wasps |
MRC2 |
15.00h |
| Zaterdag 09-10-2021 Colts | Aachen/Maastricht CO 1 | Gelre CO 1 | 13.00h |
| 10-10-2021 |
MRC 2 |
Bredase RC |
15.00h |
| 16-10-2021 Colts | Pickwick Players/Rams CO 1 | Aachen/Maastricht CO 1 | 13.00h |
| 17-10-2021 |
URC 3 |
MRC 2 |
15.00h |
| 07-11-2021 |
MRC 2 |
RC Aachen 1 |
15.00h |
